RESEARCH STUDIES

The next generation of AG1 is clinically backed.

Our innovation is driven by our ongoing investments in research and clinical discovery. We ensure the benefits of our products are thoroughly researched and any claims are substantiated by multiple bodies of research on ingredients and the finished formula. The impact of AG1 Next Gen is not just experienced, it's measurable.*1-4

Our research findings

NUTRITIONAL GAPS

AG1 Next Gen is clinically shown to fill common nutrient gaps even in healthy eaters.¹⁻⁴

What This Means

We believe in taking a food-first approach to nutrition, but even healthy eaters have gaps in their diets. Nutrient requirements are based on estimates of what most people need and they don’t account for specific genetics, gut health, or the bioavailability of nutrients. While individual nutrient gaps are variable based on day-to-day diet, and the nutrient gaps of today are not necessarily the gaps of tomorrow, we found that out of 157 total participants across four different clinical trials, 87% of individuals had at least 1 dietary nutrient gap and most participants had at least 4. Adding on AG1 Next Gen to participants' diet was clinically shown to help fill key nutritional gaps across these healthy individuals complementing their day-to-day diet.

NUTRIENT LEVELS

AG1 Next Gen improves key nutrient levels within 3 months.¹

What This Means

Nutrient levels and biomarkers are indicators of certain regulated health functions in the body because of the complex interplay between an individual’s unique biology and their nutrient utilization. Optimizing and tracking nutrient levels and associated biomarkers is a measurable indicator that a supplement is effectively supporting a healthy bodily process over time. We examined the impact of AG1 Next Gen on key nutrient biomarkers compared to diet alone and assessed its impact at the cellular level by evaluating RBC folate- a sensitive and accurate measure of folate status.

33%

increase in Vitamin C levels1

    GUT HEALTH

    AG1 Next Gen is clinically shown to enrich the gut microbiome.¹⁻³

    Over 10X Average increase in healthy bacteria in the gut1-3

    What This Means

    In three randomized controlled trials, including participants with varying diet quality, age, and activity levels, AG1 Next Gen was shown to enrich key probiotic species in the gut. This was measured using whole genome shotgun metagenomic sequencing, the gold standard tool for structural assessment of microbial taxa. The replication of results across multiple trials further validates these results and are strengthened by the fact that healthy bacteria began to decrease when AG1 Next Gen was discontinued. This leads to more confident conclusions in our research and a better understanding that AG1 Next Gen’s probiotics survive the GI tract and make it to the colon to have their desired effect.

    BIOAVILABILITY

    Key nutrients in AG1 Next Gen were shown to be quickly and easily absorbed into the body.⁴

    Folate levels were significantly increased within 30 minutes of drinking AG1 Next Gen.4

    What This Means

    Bioavailability is how well your body can absorb any given nutrient. When nutrients are bioavailable it means your body has access to use the nutrient for potential benefits. Factors such as dosage, formulation, and individual physiology can affect bioavailability, influencing a vitamin's effectiveness in performing essential functions and delivering intended benefits. Unlike some supplements that use ingredients in forms that are difficult to bypass the gut and never enter the bloodstream, AG1 used a crossover clinical trial to assess how key nutrients were absorbed and available to be used by the body.


    We found that AG1 delivers key nutrients in forms the body can absorb and use.

    What powers our research

    There are many ways to study how nutrition impacts the body. In our clinical research, we use advanced tools and technologies—alongside our academic and clinical partners—to explore the connection between nutrient intake and microbiome composition.

    Our Team

    Our research team

    Our in-house team of clinicians and scientists bring diverse expertise across nutrition, metabolism, microbiome, and related fields. We also collaborate with independent experts, academic institutions, and clinical partners to advance research and expand our understanding with cutting-edge technology.

    • Dr. Ralph Esposito

      ND, LAc — Functional Medicine

    • Dr. Laura Kunces

      PhD, RD, CSSD — Exercise Physiology & Nutrition

    • Dr. Sonia Malani

      ND, FABNO — Integrative Medicine

    • Dr. Jeremy Townsend

      PhD — Exercise Physiology

    • Dr. Trevor Kirby

      PhD — Molecular Medicine

    • Dr. Philip Sapp

      PhD — Nutritional Science

    • Dr. Caitlyn Edwards

      PhD, RD — Nutritional Science

    • Olivia Pelaez

      MS, IFNCP — Functional Nutrition

    • Alexandra Wood

      MS, Nutrition Science